It can be hard to establish what constitutes an ordinary harmful or lethal dose. However, the lethal oral dose of codeine in an Grownup is reported to be in the variety of 0.
A house teaspoon just isn't an exact measuring device and could lead to overdosage, especially when 50 % a teaspoon would be to be calculated. It is actually strongly advisable that an correct measuring device be applied. A pharmacist can provide an proper machine and can provide Directions for measuring the proper dose.
Particularly, Be sure that you discuss If you're using any of the next ahead of taking promethazine/codeine.
It is actually soluble in drinking water and freely soluble in alcohol. The molecular weight is 320.88. Its molecular system is C17H20N2S•HCl, and it's the subsequent chemical construction.
The concomitant use of Promethazine HCl and Codeine Phosphate Oral Answer with all cytochrome P450 3A4 inducers or discontinuation of a cytochrome P450 3A4 inhibitor could end in lessen codeine concentrations, greater norcodeine degrees, and fewer metabolism via 2D6 with resultant decrease morphine amounts.
Promethazine and codeine really should be used throughout pregnancy provided that the prospective benefit justifies the possible danger towards the fetus.
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, ritonavir) or discontinuation of a cytochrome P450 3A4 inducer including rifampin, carbamazepine, and phenytoin, may end in a rise in codeine plasma concentrations with subsequently increased metabolism by cytochrome P450 2D6, leading to better morphine concentrations, which could increase or prolong adverse reactions and will result in possibly deadly respiratory despair.
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric sufferers lower than six yrs of age, for the reason that Codeine Linctus Cough Syrup the combination may well lead to deadly respiratory despair On this age read more inhabitants (see WARNINGS Box Warning and Use in Pediatric People).
Printed reports with codeine have documented inconsistent results and possess essential methodological restrictions (see Data). You'll find reviews of respiratory melancholy when codeine is applied through labor and delivery (see Clinical Things to consider).
No codeine linctus dose is recommended for children for the reason that this drug has the risk of respiratory challenges and various complications.
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This medication can dry up and thicken mucus as part of your lungs, rendering it more challenging website to breathe and clear your lungs. To help prevent this outcome, consume a good amount of fluids Except if in any other case directed by your health practitioner.
A few other here medicines may well alter the blood levels of promethazine/codeine, or vice versa. Inform your Health care provider about all medicines that you choose or have recently taken.